Generic Name: sibutramine (oral) (sih BYOO tra meen) What is the most important information I should know about sibutramine? • Sibutramine has been reported to cause increased blood pressure in some patients. It is important to have your blood pressure and pulse monitored regularly while taking sibutramine. • Use caution when driving, operating machinery, or performing other hazardous activities. Sibutramine may cause dizziness, difficulty concentrating, or restlessness. If you experience these effects, avoid hazardous activities. • Do not take any other prescription or over-the-counter medicines without first talking to your doctor, especially weight-loss products, tryptophan (L-tryptophan, 5-HTP), decongestants, antidepressants, cough suppressants, lithium (Eskalith, Lithobid, Lithonate, others), and migraine medicines. What is sibutramine? • Sibutramine affects chemicals in the body that are related to weight maintenance. • Sibutramine is used as a short-term supplement to diet and exercise in the treatment of obesity. • Sibutramine may also be used for purposes other than those listed in this medication guide.